The deprecation of OMXPlayer has been problematic for one, since I rely on some custom applications which need to be able to have some fairly precise/low latency requirements between when you tell it to start playing vs when the playback actually starts, etc. I haven’t found a suitable mechanism which meets our reqs on a Pi for controlling/playing videos yet since that deprecation.

The lack of a regular HDMI output is mildly annoying but not really a problem. Audio configuration is sometimes problematic, usually not…

If a client wants to use their own Pis, getting them provisioned with our software isn’t always the easiest if the customer is techno-phobic (though that’s partly on us - RPi usage is relatively infrequent for our customers so we haven’t put the time/energy into docs and into baking an image etc).

I love Pi’s, but they just that extra bit more finicky than BrightSigns which are hyper optimized for our use case and prevalent in our customers’ equipment rooms already.