Subject Matter Expert
1,320 karma · joined December 20, 2008
companies: http://showcaseidx.com
bio & resume: https://www.linkedin.com/in/alanpinstein/
> Results: Of the 223,128 citizens of Itajaí considered for the study, a total of 159,561 subjects were included in the analysis: 113,845 (71.3%) regular ivermectin users and 45,716 (23.3%) non-users.
That reads to me like 160k people participated, and 113k optionally choose to take Ivermectin as prophylaxis.
Am I missing something ?
I don’t care what the outcome is, treatments are treatments. I have no hope for a particular outcome. It’s just bad science. And I might argue bad faith science.
Potential biases: for instance in Brazil there is a very high level of prior Covid infections. What I’d previously infected people were more likely to opt in to treatment bc they are more afraid of reinfection, and the result came from reduction due to prior immunity? What if people that took the Medecine behaved differently than non-takers?
1. For me, being physical is important. It isn’t for everyone, but if it is for you, don’t ignore it. It brings perspective, clarity, and renewed energy.
I don’t enjoy the gym rat thing, though. For me, I’ve really loved tennis & climbing. I set myself goals in each and work up to them. I use them as toys to work on mental fitness. I’ve been surprised at how much it has helped in work & life.
2. I’ve worked with a bunch of very smart people right out of school who worry about perfection. One thing I have learned that’s helpful to point out is that the school format is great for teaching a lot of information fast, and measuring a certain type of achievement, school is not life. In fact, it’s counterproductive to work/adult life. A perspective shift is needed. Think of this as a developmental phase of life. Most people experience it.
In school, you are being trained to be a perfectionist. You get one shot, and then are judged, with finality. In this game, it’s worth it to overinvest in everything to maximize your one-shot score.
In life, you can generally control the clock, and the world offers multiple rounds. So, you can play with an idea over a long time, iterating it towards more and more usefulness / perfectness. Note that the real world is much messier than school, and often the problem itself changes over time. It’s important to let go of the idea that you’ve been trained on, that there is one perfect answer to each question.
“Perfect is the enemy of done” is a great quote here.
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For your side projects, if I were you, I’d pick any one and just finish it. Not perfectly, just done. Enjoy the process, appreciate the result. Don’t judge yourself on the outcome as much as the process you used to get there.
Good luck!
That said, I can totally believe people get away with it. At many companies, many managers seem to not care, be incompetent, or not believe they can do anything about it. I could personally never be happy with myself getting away with something like that, and would quit any job that couldn’t provide productive work for me to tackle.
I heard about a greenhouse company that has programmed their climate control to match “best growing conditions historical weather”. So, they ask local experts what year / location had the best X and then they use that region’s historical weather and replay it in their greenhouse. I thought that was brilliant!
(Just realized this was Kimbal Musk that mentioned this)
Some mutations are so bad that they are fatal to the organism (don’t compile). Where a gene isn’t that important, the mutation will just confer a fitness change.
this is mediated through a variety of mechanisms. Some mutations just alter the performance of a protein, or the expression dynamics (when, for how long, and how much) of the gene expressed as protein. Many proteins don’t act directly on things but are part of complexes of proteins that perform a function, or are receptors that trigger other things, and thus many genes are “meta” in this way.
Imagine a complex sequence if gene expression during vertebrate development. At one point during elongation, a series of enzymes alter how this process starts and stops. Small variations in the performance and availability of the genes involved in this will nudge the outcome of elongation to result in a longer (or shorter) necked animal. If that is helpful for that individual, the gene will survive and flourish.
This gets more complex as in animals w sexual selection we have multiple versions (alleles) of each gene. There is also a huge realm of epigenetics and modulation (methylation, promoters, antisense, etc).
It’s really stunningly beautiful and amazing.
Of course this won't be the interactive feeling but it was pretty mind blowing to "feel" how intimate real 3d telepresence could be.
They have some demo's here:
https://research.fb.com/publications/constraining-dense-hand...
Still kinda blows me away that this issue sounded so identical to my tinnitus that I literally couldn’t tell the difference.
Overall though I’d expect 75-95% of program funds to be forgiven as they have extended the time window from 8 to 24 weeks making it much easier to use all funds in a forgivable way.
Sure enough, the local bank (Quantum National Bank) in GA, got back to me with an application to fill out before Chase even had a "form" to register interest in the program. They had a plan, and their banker was responsive via phone and email. It was pleasantly not a bad process at all.
We signed our closing papers today.
There are endless frameworks for balancing these choices. For me, they all come down to this:
Value
1. Dollar value; in either revenue unlocked or money saved (and money can be customer support time)
2. Strategic alignment; how is the item aligned with overall vision & goals? If this item is completed, does it make us stronger or dilute our value / competitiveness? This is really where stage of company comes into play.
...vs...
Cost:
1. Time; Estimated time to build/support. This can be a wag from the engineering team.
2. Risk; what is the uncertainty around the time and maintenance estimates?
Using a framework like this allows you to include architecture, technical debt maintenance, etc into your overall planning and decision process. This will help make visible to business stakeholders the true complexity of operating the product and hopefully lead to better PM decisions. Everything is a trade-off.
Remember: one of the most important jobs of a PM is to say NO. You are the process gatekeeper to how the company spends a ton of resources.
Happy to discuss further.
Not sure how unemployment insurance works in your country but in the US I spoke to restaurants and they just terminated people so that they could collect unemployment at a higher level than the business could provide income (salary or tips). Do what you have to do fast, and do it empathetically and in a way that preserves your options for restarting / re-hiring when things eventually improve.
That said, interventions can have a huge impact on the extent of that. Interventions that delay/defer/mitigate economic damage at the entity and individual levels I think can do the most to simply “pause” the economy and prevent underlying degradation while we deal w the pandemic.
Imagine the benefit of just all debt being rolled over month-by-month to the end of the loan term, and similar for renters. Defer irreversible economic decisions and go into subsistence mode. I think that will be the best best for the maximal eventual recovery. That will be the difference in a return to prior levels taking 6-12 mo vs 5-10 years.
Sadly I don’t think the US is heading in this policy direction. I half wonder if we should just do it grassroots and then there will be ample support to reimburse it via tax or other incentive.
That’s how I am thinking about it anyway.
I won’t bother re-creating the epidemiological studies as professionals have much better simulations than I could offer.
I will urge you to read up on the models before assuming this thing is “already everywhere” which also implies it won’t grow exponentially.
Also insurers are very predatory towards small groups. There shouldn’t be small Or large groups! It’s a bogus way for insurers to price discriminate and cherry pick.
The other really weird thing is that monetarily employees do not fully value the employer health care contributions. And it’s even stranger when picking coverage for families. So the idea of being able to have a flat monthly “contribution benefit” really helps both sides have more transparency around the financial benefit of health care.
If market-based health care can ever work, it has to be in an efficient market something like this. This is great news and I agree it could be huge! Good luck with the launch.
I’d love to share this with my kids but would prefer a profanity-free site to share...
Apparently it uses some nanoscale material that produces (mimics?) Rayleigh scattering.
https://www.vox.com/2015/2/18/8060673/skylight-artificial-li...
Also, their API conforms 100% to Zapier’s polling feed structure, and I managed to build an integration that syncs our customer base to Pipedrive in a few hours. A bit more time and I have it automatically moving deals along in the pipeline as users progress with using the product. That alone was game changing for our customer success team.
Thanks, team Metabase!
The way we thought about it was that OKR should not dictate 100% of effort. OKR is about prioritizing the changes that leadership wants to make at the productivity frontier of the organization. OKRs alone are not enough to direct company efforts. Leadership also needs to specify what % of energy should be spent on OKR vs other responsibilities. The OKR effort goal could be between 0-100 for different teams, or the company as a whole.
For instance, a company that needs to pivot or will die is probably close to 100% OKR effort on all teams.
This approach gets around the need to assign OKR to every activity and allows OKR to be more salient and less diluted as a tool for alignment and goal setting.
This isn't quite accurate; while some evolutionary pressures are indeed exclusively short-term, not all are.
For instance, ability of eukaryotes to have multiple alleles of individual genes combined with sexual reproduction allow populations to maintain a large diversity of alleles and genes, which have the effect of allowing large-scale "split testing" and also "alternatives" for different current environments that may appear over time.