2,507 karma · joined August 17, 2010
https://tad.me.uk/
Clearly, if you are fairly consistently sticking to 2-minutes showers, that's going to be more economical than baths -- even with some degree of sharing.
If you have a family, can you share a bath (taking turns)? That's a substantial and fairly easily-achieved saving.
If you've got a garden, adding a gray-water collection system also makes things that little bit less wasteful, at least in the summer (but I suppose that would also work with a shower too...)
There’s quite a lot of pre-Cisco history in this paper: https://www.cs.indiana.edu/~dyb/pubs/hocs.pdf
Those mutation descriptions are called HGVS (Human Genome Variation Society) nomenclature. In the example you give, "c." means that it's in a (protein) coding region, 345 is the position within the region, and G>E would be the change (although E isn't a valid "letter" in DNA sequence, even if you allow ambiguity codes -- you'd normally see something like G>T there instead).
Complications include:
1) You need to know which gene this is relative to.
2) The "coding sequence" for the gene isn't always perfectly defined, due to splice variation and different versions of the annotation. Ideally, you'd see this code relative to a specific splice variant (which might have an ENST identifier, from http://www.ensembl.org/). But it depends...
More at http://varnomen.hgvs.org/ if you're curious.
https://steveblank.com/2009/12/21/the-elves-leave-middle-ear...
(Slightly startled to learn that was published nearly a decade ago!)
Being outside on my own is pretty good in general. Walking or cycling are the defaults, but maybe count as exercise? I've recently started riding a motorbike and spin on some quiet-ish open roads can be pretty rewarding...
They’ve gone for “cloud services” instead. Drastically, drastically, less inspiring — and also pretty competitive. What happens if Amazon drop their prices a bit?
That's an interesting take. But my experience is that there is a non-negligible set of people who would see a lifetime spent working on their chosen problem to be well-spent, even if they don't eventually succeed.
[1] although... "thinking" can stack surprisingly well with some activities we'd consider leisure, like walking or (at least in my case) gardening. So maybe this isn't really going to be 65hrs/week at a desk...
In some ways, I wish this were the case. But my reading is that Apple's custom processors are still far ahead of the competition, and last time I looked it was hard to match Apple's fit and finish, especially if you are looking at anything other than the very top of the Android market. And for something that you keep in your pocket and handle regularly, a feeling of solidity is worth something.
It's a tragedy that you can't buy an iPhone with an unlocked bootloader. There's some interesting potential for innovation there.
(This is even more true in some other market segments. The hardware for the last couple of generations of Apple Watch is amazing, and that makes OS-imposed limits on what third party apps can do tragic).
How does that explain the large number of Bay Area, on-site-only startups?
One thing that's adding to the "frustration factor" of the CSS problems is that the updates seem rather racy (Firefox 63, MacOS), in the sense that if you edit further while an update is already running, it doesn't seem to trigger a further update. Makes moving things around 1px at a time more annoying that it should be.
(I'm another one stuck with a just few pixels difference on the triangle for CSS Puzzle 7. Once someone's claimed the final prize, might there be an option to skip through to the later puzzles?)
I know a number of people thought some of the "simulation with lots of details to keep track of" problems were a bit over the top this year. Personally, I rather enjoyed them, and in particular found day 15 really satisfying to complete. Not something you'd want to do every day, but it's good to have some problems which pose a bit of a challenge without turning into a "can you pattern-match this against an algorithms textbook" exercise. The overall breadth and balance of problem types was impressive as ever.
I hope it's back next year!
In the former case, demonstrating that what they've done isn't "pure genius" shouldn't be too hard.
In the latter case, I think that -- especially if this is something you need reasonably quickly -- there's a good argument for focussing on value delivered and fixing actual, observable, bugs rather than spending too long worrying about the internal details. If need be, it can always be quietly rewritten once the dust has settled.