niels_olson

I interviewed at Sikorsky back in the day. Sort of wish I had pursued it, because the factory floor was amazing, but the manager reminded me of a guy from The Sopranos, and then I got into medical school. But that floor, man. Swashplates. Have you ever seen a swashplate, naked and alone on a pallet? Thin wall machining. I mean, goddamn, that was some sexy machine work. But they wanted me to run business analytics for government cost-accounting programs. Fuck. That. Also, medical school.

Soundgarden’s Black Hole Sun for those of a certain age: https://youtu.be/3mbBbFH9fAg

Actual paper here: https://pubs.aeaweb.org/doi/pdfplus/10.1257/aer.20162015

You should probably read the actual analysis (free, 40+ page paper), they accounted for all sorts of things. https://pubs.aeaweb.org/doi/pdfplus/10.1257/aer.20162015

They’re going to do their version of “Other bets”.

My first job out of college was as a junior engineering officer on a ship. I had taken naval architecture and the daily draft report was part of my job. The fuel king had a spreadsheet where the engineering watch input all the tank levels overnight. I added a sheet that took that data and solved all the tank problems, bouncy, incline, etc, and printed the report. So instead of two hours of number crunching, or one of my enlisted guys doing what he did (which was basically copy forward and subtract an inch a day), the report was completely automated, with fore, aft, and center draft. With zero human effort.

Apparently the guy who took my job when I left had a nervous breakdown. I feel a little bad about that, but not really. He should have paid attention in class.

I believe socialism has a pretty specific definition: government ownership and control of the means of production. Which is easy to grasp for steel mills, power plants, and hospitals. A bit trickier in the creative economy and the gig economy.

Unfortunately, some people are going to read this wrong. For example: I know some folks who have "second dinner" after 8 pm. Their children are definitively obese, and I can see them citing this study as a reason to keep eating "a meal called dinner" after 8 pm.

How do you propose to infect cells deep inside solid tumors?How do you target cells that have lost cell surface markers? Your example, p16, is used in many cells intermittently, or only in certain microenvironments . How do you deliver? IV, topical, tumor injection (if so, what about needle tract seeding)?

You may be interested in the FedRAMP marketplace: https://marketplace.fedramp.gov/#/products?status=FedRAMP%20...

I donated white 2007 to the local Lego robotics team and it's still winning.

There is: they are intertwined with other regimes:

  * The international banking regime
  * The US legal regime for corporate purposes
  * Many other national regimes for operating purposes

> I can't think of a single other example of a single-purpose CA like this.

Department of Defense: http://www.disa.mil/enterprise-services/identity-and-access-...

Look up Sanger sequencing.

There are regions with sparse coverage due to higher concentrations of C-G bases. This can make alignment results less reliable. Plasmids may interfere with alignment or need to be isolated out before or during library prep. And you want to detect and discard any members of the population with any evidence of cancer, genetic disease, etc.

And you need good population coverage. What's a normal variant? Newer methods propose a graph alignment instead of just trying to build a single sequence reference genome.

Personal opinion based on anecdotal evidence: population mobility has increased career opportunity at the expense of the opportunities afforded to young families through staying close to home. From newborn to age N, local gandparents can be a godsend. In any family's case, which grandparents are nearby may be crucial, but if you came from a nuturing home, moving to a different timezone has definitely negative, high stress consequences in the young home.

I'd go beyond "general problem-solving skills". Physics gives you high quality math training (albeit somewhat truncated with respect to number theory), coupled with demanding experimental methods, and a deep, principled understanding of the foundations of the universe. Nothing is beyond your reach. Any other quantitative or logical discipline is just laying there, waiting for you.

Theory vs experiment. More data always wins.

Then please cite the better ones...

Matt Cutts now works for Defense Digital Service....

My sense is that the major issue is not the algorithms. The algorithms are plenty fine today. The major issue is data. Not "more" data. Just data. There are vast swaths of the economy where people simply haven't figured out how to digitize the data yet. They have no idea the gold mines they are sitting on.

Imagine everyone who never took multi-dimensional calculus in college (most of humanity). Where are they today? Those folks have data they're not using.

> also ordering services such as use of the clinic, assistants, supplies, and so forth

For things like moles, a big chunk is the pathologist's professional fee, as well as the technical fees for whatever additional studies may be needed. "It's just a mole" can become "I'm very sorry, but you have melanoma, we'll be excising most of your cheek on Tuesday."

The methods of Medicare pricing were established by DeBakey's subordinates when Johnson pushed Medicare through. It's backroom deals all the way down.

Can't vote on those, and it's five hysterical pacifist comments who conveniently forget that the DoD also owns the "homeless missions" by default, and complained when Obama didn't send more troops to Allepo.

Look, this video is aimed at mid-level to senior officers: leaders tasked to keep their people alive and executing the mission (humanitarian aid, asset extraction, etc.). This is a think piece for people who will go into harm's way.

Ah, cholesterol plaques in arteries are in fact the ghost of inflammation past, and specifically macrophage-mediated inflammation. In medicine this is far from a departure from the prevailing hypothesis -- it is a consolidation of multiple lines of evidence.

That said, you will be on-site and likely working on the most interesting problems.

They are building ahead of the collapse of their labor pool as the population greys to an precedented degree.

Karpathy's explanation in CS231n is great: for any computational unit that is a function, you can calculate a derivative. So propagating the derivative backward through the function, just aplly the chain rule. This is much with simpler functions, so understand your algorithm down to the smallest computable units in the graph.

My experience with development cost estimates suggests the easy parts are easy and the interesting parts might as well be splatter-paint.

Every atom of every element heavier than iron is stardust (1). Uranium is no more fossil than gold is.

(1) Most of the lighter stuff is stardust too, but there's some small number of heavy nuclei that decayed down to more stable, lighter isotopes, which ultimately leads to iron, the most stable of all.