notshift

Your first link seems to be in support of a keto diet, your second link is a correlational study, and your third link is a mouse study.

You can check my other comment above for a bunch of other sources/studies on keto diets reversing Alzheimer's symptoms if you'd like.

All the books I read cite plenty of studies, including the one I mentioned, which is why I call it "one step above scientific studies", but you get called a whacko nonetheless if you or the author hold any opinions even moderately outside of the mainstream dialogue / mainstream medicine.

My original comment on this thread is at -1 even though what I said was factually correct (and I found all my linked sources above via exactly what I said, a quick Google search). Another of my comments on this post has the classic reply "ah but the author of your study has been accused of quackery if I google his name".

So I'd say a bit more open-mindedness would be in order.

Some nuts will have trace amounts of mold on them, depending on how they're sourced or how long they're sitting around. I've read that it's most common on pistachios. Not sure to what extent it actually happens but rinsing the nuts certainly won't do any harm.

How do you prepare your salads, if you don't mind me asking?

I agree. I'm not talking about a one-off study showing a minor improvement though (which would be likely to not replicate, etc.), I'm referring to a much stronger effect which in principle is addressing the origin of the disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720297/ - a review of various studies, concludes that "Keto diet may modulate a broad array of metabolic and signaling changes underlying the pathophysiology of neurodegenerative disorders. Based on the limited animal studies and clinical trials, keto diet has beneficial effects for enhancing mitochondrial function and cellular metabolism. It is associated with improved cognitive performance in elderly adults with Alzheimer's disease. The improvement of the cognitive outcomes depends on the level and duration of ketosis."

https://alzres.biomedcentral.com/articles/10.1186/s13195-021... - study from video I linked above, concludes that "patients on the ketogenic diet improved in daily function and quality of life".

https://academic.oup.com/advances/article/11/6/1583/5864685?... - another review, concludes that "The results underline that, collectively, the efficacy of ketogenic therapy in MCI/AD appears promising, indicating that it is more than a symptomatic remedy (137). Nevertheless, research is still scattered and heterogeneous in terms of study design, intervention, participants, and outcomes of interest."

https://pubmed.ncbi.nlm.nih.gov/15123336/ - study on MCT oil which raises levels of ketones, abstract says "Higher ketone values were associated with greater improvement in paragraph recall with MCT treatment relative to placebo across all subjects (P=0.02). Additional research is warranted to determine the therapeutic benefits of MCTs for patients with AD and how APOE-4 status may mediate beta-OHB efficacy."

Additionally Alzheimer's is actually referred to by a large number of folks in the field as "type 3 diabetes" & as far as I understand there is a large amount of overlap between the two diseases; we have studies showing that diabetes can be nearly or totally cured by carbohydrate restriction:

https://pubmed.ncbi.nlm.nih.gov/29417495/ - of 349 participants, 94% were able to eliminate or reduce insulin therapy after 1 year (57% discontinued their prescriptions entirely).

The book "The Alzheimer's Antidote" by Amy Berger is a great resource if you are open minded enough to be willing to look at informational resources once step above scientific controlled studies (unfortunately many folks are not).

I think I read that Italians use something like 3oz/day of olive oil on average, aka 6 tablespoons. I wouldn't eat 8 tablespoons directly (lol) but if you just put a good amount on all your meats and vegetables it adds up a lot faster than you think.

If the diet can reverse the usual decline and ultimately cure the disease given enough time, surely that would imply it would also prevent onset, no?

I'll take a more detailed look into the other resources I've studied and post another reply in a few hours.

Mice trials don't interest me much. Human trials of various diets for Alzheimer's have been done along with lots of individuals who have tested it on themselves or family members with positive results.

I can't find one of the more comprehensive studies I was looking at before, but a quick search pulls up this video which discusses a recent human trial which showed significant improvement on the keto diet (links to the study in description):

https://youtu.be/jK6-r1zWOI0

Not sure what evidence you've been looking at; from what I've read the opposite is true: Keto diet can be an effective treatment for Alzheimer's.

https://m.youtube.com/watch?v=jK6-r1zWOI0

There have been several studies done showing that a healthy keto diet can reduce or even reverse Alzheimers symptoms in many patients. Just do a quick Google or YouTube search, lots of content on the subject.

I asked you for an alternative and you didn't provide one. Are you interested in solving problems or just throwing stones?

If you think those two are cranks, with their piles of credentials and active practices with tens of thousands of satisfied patients, who would you recommend I follow for health-related content instead?

There are certainly quacks out there, but there are also folks with piles of credentials who describe what they do as functional medicine, who operate strictly according to the latest science, and who have massive beneficial impacts on the patients they see, many of which who have been failed by the mainstream medical establishment.

Descriptions like the above which seek to attack and discredit any form of alternative medicine will always exist because mainstream medical practice first seeks to enrich corporations and only secondarily tries to help patients. (Not on an individual level, but structurally.)

I'd invite you to check out the YouTube channels or any of the books written by Dr. Mark Hyman or Dr. Gundry; the content they put out is incredible and has had a huge positive impact on my life.

You probably have much more knowledge than me then, but based on the reading I've done, we now basically know of certain genes that make people far more likely to get diseases like alzheimers or even to get a diagnosis of autism (genes which make the body unable to detoxify heavy metals) - it seems to me like that sort of information is probably instrumental in being able to fully understand and eventually cure or prevent these diseases, no?

I don't know much about the services 23andme offers, but genetic testing is used extenstively and effectually by functional medicine practictioners every day, to do things like checking a patient's predisposition to certain illnesses, or to see if their body requires an unusually high or low amount of certain foods / nutrients, etc.

It's true that some reject the idea of group selection, but there are lots of scientists too who embrace the idea. Lots of very good talks/interviews on YouTube with scientists & researchers on the subject.

IMO there are too many phenomena that are very difficult to explain only with individual selection, but trivial to explain with group selection.

Not sure about the claim that evolution favors groups whose rejected members die (not sure what rejected even means in this context), seems to me like that would depend a lot on environmental context and vary across species and across time.

React only re-renders a component if the state changes, the props change, or a parent component re-renders. In my app, I only have one component where I needed to break out of the vdom, and none of the parent tree ever re-rendered (except when navigating to a new page, which correctly tears down the component), so it was as simple as just one useRef to grab a reference and one useEffect to pass it to my other code after the component rendered.

From your article:

there is not a single absolute genetic difference, meaning no single variant where all Africans have one variant and all Europeans another one, even when recent migration is disregarded. It is all a question of differences in how frequent different variants are on different continents and in different regions.

The title is is not representative of what the article is saying; no serious scientist is making the claim that race is a social construct. They're just saying we shouldn't make medical or other assumptions about individuals based on race, which is of course true.

The idea that races don't exist is a postmodern rejection of science based on a political agenda, and you should be skeptical of folks pushing it. If you study biology or evolution at any reasonable length the notion is just silly.

afaik, once an app gets big enough, using a virtual dom actually produces a smaller build than using Svelte's compilation model, and it also places fewer restraints on the ways you can structure your code.

Svelte's model isn't strictly better; like almost everything in programming, it just has it's own set of tradeoffs.

Relevant tweet thread: https://mobile.twitter.com/dan_abramov/status/11354244236689...

I was addressing your comment on equality of outcome:

And if you see that the gap is caused by the distribution of the type of work, for example, raceX is more likely to do work that pays more than raceZ. Well that's also an issue, because we value equal opportunity between races, and the assumption is if opportunity was truly equal, the data should not show a big gap in the choices of work made between races

Do you think personality wouldn't have an effect on job selection?

The variance of personality between individuals is around 40-60% genetic in origin (i.e. genes have a huge impact on personality). Given this, if you believe personality has any impact on career selection at all, a differing distribution of career selection between sexes and races would be an expected outcome, no discrimination or bias necessary.

Tesla publishes data on accident rates with and without autopilot, and the rate with autopilot engaged is lower. The problem is, that data is mostly meaningless because people don't use autopilot in conditions when an accident is most likely to occur.

I suppose you'd have to compare against only manual driving in good conditions to make a fair comparison. Not sure that data exists anywhere.

Question: Where can I find these companies that heavily bias towards hiring young people / new grads?

I'm 23 with 1.5 YOE and so far my experience has been the opposite: Startups and companies I want to work for only have open positions for seniors and seem to mostly discard my applications, despite the fact that I've been programming in my free time for practically a decade now and consider myself a strong developer.

At this point I've honestly just given up and decided to work for crappy companies for a few years until I have the resume to get a job that I actually want.

Waymo already "self-drives" today, it just is extremely slow at making turns when the road is busy, and if there is any kind of unusual obstacle on the road (such as construction cones that require you to drive partially in another lane) it just stops completely and has the rider wait for twenty minutes for a manual operator to come and take over.

Those two obstacles won't be overcome until AGI. At best their frequency will be brought down a bit but not by nearly enough orders of magnitude.

What slow cooker recipes do you make most often? I need some ideas

Carbs themselves make most people hungrier, because humans evolved an instinct to load up on fruit calories during the limited window that fruit was in season, so that they could make it through the subsequent winter when food was more scarce.

Probably also has to do with the fact that bread has so little actual nutrition. The body isn't getting what it needs, so it prompts you to eat more.

From the reading I've done, whole wheat bread isn't much healthier than regular white bread. Humans are supposed to be eating nutrient dense foods - bread has hardly any, and carbs break down into sugar. Classifying both as processed and thus unhealthy makes sense to me.

For longevity, the best you can do is the right vegetables with meats and fruits in moderation.

I did the same this year, but found that FreeTaxUSA's support for crypto transactions was basically non-existent. Filing through TurboTax was way less work than what I would've had to do with FreeTaxUSA.

If you made a peach smoothie out of nothing but pure peaches, it would be identical to eating the peaches, I'm sure.

I am also not a nutritionist, but from my reading processed foods are bad because (1) they just have far fewer nutrients, vitamins and minerals that our body needs to function, (2) the additives and chemicals that are added sometimes harm our body directly and/or require the body to dedicate resources towards removing, or (3) they harm our microbiome by feeding bad bacteria which similarly produce stuff that isn't good for your body and damaging the good bacteria which we need.