Alex3917

This has the potential to be a precedent-setting case, and I'm not sure how I feel about that. I agree with her daughter that this is horribly done, but should that matter legally? That is, would the situation be different if the same idea were well executed?

I was only able to make it through a minute of this or so, because it was so unsettling, but it's hard to know whether or not that should matter.

Conspiracy theory: The “Dynamic Island” widget sounds very similar to the name of Brett Victor’s consulting shop, Dynamicland.

> we need better ways to store energy from solar power.

Why? I understand that for a normal website you always want to use the closest server possible, but for queries that take 30 seconds on average anyway, why does it matter if you're adding an extra 250ms to get it from the opposite side of the world?

If AI can legitimately replace human labor, why would anyone care if it takes an extra few milliseconds?

> making an accessible HTML email is even more difficult than making an accessible website due to the limitations imposed on HTML emails by most mail client

FWIW I have a Gmail Add-on that reformats the garbage HTML produced by email clients and makes it accessible. (And if you're wondering what an add-on is, it's similar to a Chrome extension, but without the security risks because the code runs on Google's servers rather than in your browser.)

https://prettyfwd.com/

Such a timeless story. There's literally a murder suicide case being tried right now less than ten miles away from where the movie was filmed, allegedly involving a somewhat similar scenario. (I don't want to give away the plot.)

> FREE LIKE FREE BEER. No fees for download, registration, licensing or deployment, even you distribute Firebird as part of your commercial software package.

Wouldn't this be free as in speech? I thought "free as in beer" meant no cost, but with restrictions. E.g. you are allowed to drink beer at the party, but you aren't allowed to bring extra cans home with you.

RDS databases only allow alphanumic names -- no hyphens, underscores, spaces, etc. Even though it's a small thing, it's an absurdly bad user experience to have to enter the exact same name two or three times spelled differently just to set up some basic AWS infra.

To me the wild ones generally taste like a mix of unripe pear and diesel fuel. Extremely unpleasant, so it's no wonder that so many people who have tried pawpaws think they don't like them.

I've also ordered from these guys, they are good.

Just don't get NC-1, Mango, Rappahannock, Prolific, Overleese, Wells, or PA Gold.

Don't get me wrong, if you get one of those when they're perfectly ripe then it may well still be a completely life changing experience. But you can also do better, and given then you're going to have them for the next 25 years, it's worth doing the extra work to get the absolute best cultivars you can rather than just buying the first ones that are in stock, even if it takes an extra year to get started.

Yeah these are the cultivars I'd start with:

KSU Chappell, KSU Atwood, Wabash, Shenandoah, Susquehanna, Potomac

If you're on the east coast and willing to drive to New Jersey, then I'd recommend ordering from Charlie West: https://sites.google.com/view/westfarm

If not, then Peaceful Heritage is very reputable, the main problem with them is that their grafted pawpaws only go on sale one day per year and are completely sold out in 20 minutes.

If you can't get from them, then your options are OneGreenWorld, StarkBros, and the other usual suspects.

Logees also sells Shenandoah and Susquehanna as a set for super cheap and they typically have a lot of inventory in the spring, so I'd recommend picking up those cultivars there and getting them shipped.

Also, Cliff England no longer ships trees, but still sells to customers that are willing to drive to KY: http://nuttrees.net/

Yeah my personal rule of thumb is not to eat more than two per day and six per week, and to periodically check Google Scholar for new research. If you're going to cook with them, I'd recommend sticking to recipes that involve adding them to cooked food (e.g. as a layer on top of a cheesecake) rather than applying heat directly to them. And also to eat them only during the month or so per year that they're in season, rather than freezing them and eating them year round.

And if you haven't already seen it, here are Neal Peterson's recommendations for safe consumption:

https://www.petersonpawpaws.com/are-pawpaws-safe/

His recommendations are notable mainly because he's the one who kickstarted the pawpaw renaissance and released many of the most popular (and best) cultivars on the market today.

I'm not familiar with DNP, I'd have to look into it more. I have read a lot of the research on metformin, because that is also suspected to act like a mitochondrial complex I inhibitor in some circumstances. (Although it seems to act different ways in different situations, so no one really knows what's going on there yet.) But regardless, Peter Attia considered metformin to be a longevity drug (at least before he decided it might be hurting his muscle growth), so there may be a lot of precedent for using mitochondrial complex I inhibitors for health benefits, assuming metformin actually has that mechanism of action.

So the Annonaceous acetogenins are what's called mitochondrial complex I inhibitors. Basically the way they work is they cause a buildup of radical oxides within your mitochondria, which decrease how efficient your mitochondria are at producing energy. In small doses, this is probably a good thing -- you give your mitochondria a good workout, and then eventually some antioxidants clear out the radical oxides and your mitochondria end up stronger than before. But in sufficiently large doses, you will start killing off your mitochondria, and if you kill enough (likely over several decades) it will cause something called Progressive Supranuclear Palsy, which is fatal.

The good news is that there is only one recorded case in history of someone who is suspected to have gotten PSP from eating pawpaws, a grower in New Jersey. The acetoenins in pawpaws have a fairly low bioavalability, so it's probably only a significant risk if you are 1) eating large quantities 2) doing something to increase the bioavailability of the acetogenins, e.g. cooking them with fat or maybe mixing them with alcohol.

If you eat moderate quantities out of hand, then most likely you are just reducing your cancer and diabetes risk, without taking on any increased risk of PSP. And since cancer and diabetes kill hundreds of times more people than PSP, overall eating them out of hand is almost certainly a net positive for your health -- especially when you compare them with the health effects of ice cream or whatever other dessert you'd have otherwise have been eating in their place.

That said, the cultivars that are specifically known to be low in acetogenins are: Sunflower, Wabash, Potomac, Zimmerman, Wells, Mango, Shenandoah.

Of these, the ones that are actually good are Wabash, Shenandoah, Sunflower, and Potomac. So if you just want to grow cultivars low in acetogenins, grow at least two of those four.

There are enough people growing pawpaws now that they will increasingly start showing up in farmer's markets over the next five years or so. The fourth generation of pawpaws (i.e. four generations improved from the prize-winning 1916 Ketter tree, which was selected from the wild) didn't start getting released until the mid 90s, and the fifth generation didn't start getting released until the mid 2010s. And it's at least decade between when a new cultivar gets release and when it's widely available to purchase, and then it takes another 5 - 7 years to grow to maturity after that. So it's really only within the last five years or so that it's even been possible to start growing commercial-quality fruit.

I started growing them in 2018, and even though that's not that long ago, the best cultivars you could get back then were complete garbage compared with what you can get today.

> why we feel it's OK to pirate news articles, but not other IP.

Once the NYT pays reparations for the Iraq war, I'll be the first to stop pirating it.

If they were using a deny list, that sounds like an intentional backdoor.

Or just play Go online.

It's literally the most foundational part of self driving.

> I'm sorry but there's no way that Subaru EyeSight can "trounce" FSD.

I mean that's what literally all of the data shows, e.g.:

https://www.caranddriver.com/features/a24511826/safety-featu...

> They have a relatively small team when compared to Waymo, at least at the research/state-of-the-art level.

Sure, but in every independent test, Tesla's smart driving capabilities get completely trounced by Subaru EyeSight. Does Subaru also have vastly more PhD researchers than Tesla?

I meant a Django template, e.g.: https://www.valentinog.com/blog/django-project/

I haven't look at this particular project, but having to type the same information into multiple env files is unfortunately pretty unavoidable. Making a Docker / Django project instantiable via template and then runnable locally and deployable in production unfortunately involves 5+ different variable templating systems, which each require their variables to be declared in different files and formats.

FWIW I've also had the same experience; the last version of Django where upgrading took a non-trivial amount of time was 1.8, because it changed how isolation is enforced within test cases. Since then it's rarely taken more than an hour or two, regardless of how big the codebase is.

> Just overlook one instance where this is happening in a loop and say goodbye to performance and hello to timeouts left and right...

FWIW they do give you assertNumQueries in the testing tools, which makes it relatively easy to catch this as long as you have tests.

> The winners will have to prove by 2030 that their intervention can turn back the clock in older adults by at least a decade in three key areas: cognition, immunity, and muscle function.

Can't you already get that just by exercising?

Are the standards for building accessible PDFs worse than the standards for building accessible websites, or are they just not as commonly implemented?

> we are talking about freeing up tons of knowledge from a "good for consumption/bad for distribution" format.

FWIW PDF is actually great for distribution. It allows you to invisibly embed all the raw data used to generate the document that the end user is seeing, in whatever format you want. So if you are generating your PDFs by using PrinceXML to render HTML, you can embed the raw JSON used to generate all of the text, graphs, charts, etc. Now most people don't actually do this of course, but that isn't the fault of the spec.

> Having a direct link to S3 + existing connectors built in feels like a strong competitive moat.

Not really; the hard part is processing the data from each of these sources, not downloading the data from the source. Sure, any company that wants to compete is going to need to raise at least $30m just to get to the same minimal baseline level of support, but that was already the case even without this announcement.

In terms of whether this product will win the market, I honestly doubt it. Figuring out how to best process the data from each source to yield good results is going to be highly subjective, and Amazon's culture makes it unlikely that it will succeed here.

(As someone with a company that offers an API to pre-process email for LLM ingestion, fwiw.)

So ePadd redacts everything except the named entities, but that still means going through each message by hand to ensure that the entities generated by the NLP software are correct. Plus the time spent fixing ePadd to make the import run correctly with his non-standard email client, the time spent negotiating permissions and restrictions related to the collection, etc.

C.f.: https://github.com/search?q=repo%3AePADD%2Fepadd++knuth&type...

His secretary may have typed them, but if they were mostly written by his secretary then Stanford wouldn't have paid to have them archived. Even though the messages are mostly redacted, actually going through and doing those redactions is still hundreds of hours of work.