kasperset

This reminds me of https://crypto.stanford.edu/PwdHash One of the first "password manager" I used.

My thoughts exactly!

Start with the platform one is already using for data munging/transformation. I think R with its ggplot2 library is very good. Python's Matplotlib is also not bad. ObservableHq is also good when the data is closer to visual representation. Overall, I find the data transformation technique does the 80% of the work when it comes to data visualization.

Not for Linux :( Works in MacOS but paid software. https://www.stclairsoft.com/HistoryHound/

Rarely do I see a mention of Ultraedit. Although it is a paid software, it was nice and polished as expected. However, I have very limited experience with it. Any thoughts?

One of my favorite applications in R that can make Graphviz like plots: http://rich-iannone.github.io/DiagrammeR/index.html

I would suggest reading this paper.

Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., Watkinson, P., Khunti, K., Harnden, A., Coupland, C. A. C., Channon, K. M., Mills, N. L., Sheikh, A., & Hippisley-Cox, J. (2021). Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection. Nature Medicine. https://doi.org/10.1038/s41591-021-01630-0

Specifically follow this figure: https://www.nature.com/articles/s41591-021-01630-0/figures/1

Basically the risk is higher for people under 40.

In that cohort, risk is highest with the Moderna vaccine within 1-7 days following first and second dose. The risk is higher with the 2nd Moderna dose as compare to Pfizer one. I suspect it may be due to dosing.

Risk is also present with the Pfizer does but more so with the 2nd dose.

Covid-19 itself can also cause Myocarditis.

"The risks are more evenly balanced in younger persons aged up to 40 years, where we estimated the excess in myocarditis events following SARS-CoV-2 infection to be 10 per million with the excess following a second dose of mRNA-1273 vaccine being 15 per million."

Overall, the risk is non-zero but very low compare to actual background rate of myocarditis.

"The incidence of myocarditis is approximately 1.5 million cases worldwide per year. Incidence is usually estimated between 10 to 20 cases per 100,000 persons." Quoted from Kang, M., & An, J. (2021). Viral Myocarditis. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK459259/

So we have 1.5 cases per 100,000 (Moderna vaccine) vs 10-20 per 100,000 (Background).

Perl is expressive but the code can be hard to read. In general, Python is readable because it enforces the indentation and other language design choices.

Python also got heavyweight libraries such as Numpy and Pandas which put it in the front. Perl do not have have such well known libraries as far as I know.

For sure but an average person does not want to figure that out. Apps are marketed crazily and that lives little room to think about those alternatives.

Steve Jobs had the similar idea so he opposed the idea of App store initially but as we know he gave up and we know the result. I think idea is to present "containerized" experience so the user thinks they are dealing with the app exclusively. There is some personal appeal to app whereas web page seems like a general purpose app which some users feel they may have subpar experience.

I think non-techie people are more accustomed to "exclusiveness" where you just reach the app directly as compare to having the choice the entering the webpage address or even clicking a bookmark. Sometimes it is more about human psychology than technical issues.

Shannon's entropy is also used for calculating one of the measure of alpha-diversity in ecological and microbiome studies.

I like this idea. However to me it is similar to using à la carte tools/programs along with bash script or DSL such as Nextflow. More often these stand-alone programs are already written in compiled languages. I am sure Seq will allow to build customized programs as compared to scripting or gluing programs.

html link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041510/

Dropbox remains for me the best syncing software especially with Delta sync. No issues like file name restrictions that I have encountered in OneDrive. I like Google Photos and it remains my favorite photo storage solution. I find Dropbox more user friendly with features like folder rewind. For sure, I would like cheaper pricing plan with 200GB Storage.

Also like to add the fitness products such as Peloton and Hydrow to this hidden subscription category.

Most of my bookmarks are saved in PinBoard. I also tend to use Zotero or Diigo to store my bookmarks. Occasionally, I will browse them by dates to see what I was reading x years ago. Sometimes, I will search them. I do not like to use tag so just use plain search in tools mentioned above. However, most of the bookmarks have not been opened at all. There is also the issue of linkrot and I found that Zotero works best for me to save them offline.

It is available out of box. I was referring to "Quick Add Next". https://www.sublimetext.com/docs/multiple_selection_with_the...

I miss multiple cursor on non-contiguous text with BBEdit. I feel like this feature should be standard. I was blown by that feature when I saw it first on Sublime text.

This could be the case. I remember this controversy few years ago about Tardigrade genome. The problem was that other paper said that "foreign" dna was the probable reason behind cryptobiosis in Tardigrade. This particular paper found that it was mostly likely a contamination.

Koutsovoulos, G., Kumar, S., Laetsch, D. R., Stevens, L., Daub, J., Conlon, C., Maroon, H., Thomas, F., Aboobaker, A. A., & Blaxter, M. (2016). No evidence for extensive horizontal gene transfer in the genome of the tardigrade Hypsibius dujardini. Proceedings of the National Academy of Sciences, 113(18), 5053–5058. https://doi.org/10.1073/pnas.1600338113

I found few case studies for blood clotting which could be due to autoimmune origin. However, no formal studies yet that I could find.

Maayan, H., Kirgner, I., Gutwein, O., Herzog-Tzarfati, K., Rahimi-Levene, N., Koren-Michowitz, M., & Blickstein, D. (n.d.). Acquired Thrombotic Thrombocytopenic Purpura: A rare disease associated Acquired with BNT162b2 vaccine. Journal of Thrombosis and Haemostasis, n/a(n/a). https://doi.org/10.1111/jth.15420

Yocum, A., & Simon, E. L. (2021). Thrombotic Thrombocytopenic Purpura after Ad26.COV2-S Vaccination. The American Journal of Emergency Medicine. https://doi.org/10.1016/j.ajem.2021.05.001

I found one relevant article (Response to the article) on PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833091/

"Although this is not the case of the authorized COVID-19 mRNA vaccines, future formulations containing adjuvant like TLR agonists [13] may exacerbate pre-existing autoimmune or autoinflammatory disorders and should therefore be discouraged in this cohort of patients."

I guess this mostly relates to the "packaging" of the mRNA vaccines relating to the entry in the cells.

I guess older generation drives running on USB 2.0 would be slower but run cooler.

Just saw this "Build Mail app extensions" https://developer.apple.com/videos/play/wwdc2021/10168/ Does this mean we will get content blocker for email then?

Glad that it has section on style guides and packages that help with styling R code such as "lintr" and "styler". Looks fairly comprehensive even for non-Epidemiologist.

Never tried but been using Colab pro and for most part it works pretty well even though I use it for R kernel. The most difficult part in such notebook environment is the installation of some non-standard R packages such as "Vegan" and "Phyloseq" but otherwise no major issues.

I really want to love Julia language but the overhead of package loading annoys me. Perhaps this may be just me being lazy or spoiled after using R packages or Python libraries.

This has been discussed before but I am watching the development of https://github.com/fonsp/Pluto.jl so that it can provide some solid alternative.

I remember there was a chapter in one of the Marathi textbook with the initials "Pu La". Not sure which grade. In any case, I was not aware what a talented person he was. Nice!

Come with the power adapter. With the size constraints, I guess it was not possible to have it built in.

Although not a solution for tab problem, apps like Historyhound may help to some extent getting over that losing all the information fear.